烟碱型乙酰胆碱受体α9/AChRα9抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 烟碱型乙酰胆碱受体α9/AChRα9抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. 烟碱型乙酰胆碱受体α9/AChRα9抗体 These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. AChR alpha 9 is the only AChR found in cochlear hair cells. In adult rat cochlear outer hair cells (OHCs), AChR alpha 9 is expressed primarily in basal regions,烟碱型乙酰胆碱受体α9/AChRα9抗体  where it is a component of the cholinergic receptor, while in inner hair cells (IHCs), it is expressed primarily in apical regions. The alpha 9 subunit mediates efferent synaptic transmission between cholinergic olivocochlear fibers and OHCs. One of the main functions of the AChR alpha 9 channel is to provide a pathway for calcium ion influx. AChR alpha 9 may also influence the arrival of efferent axons.

烟碱型乙酰胆碱受体α9/AChRα9抗体 Also known as:

Cholinergic receptor nicotinic alpha 9; Cholinergic receptor nicotinic alpha polypeptide 9; HSA243342; MGC142109; MGC142135; NACHR alpha 9; NACHRA9; Neuronal acetylcholine receptor protein subunit alpha 9 precursor; ACHA9_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .

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Immunogen: KLH conjugated synthetic peptide derived from human CHRNA9.

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烟碱型乙酰胆碱受体α9/AChRα9抗体 Predicted Molecular Weight: 52kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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