血管紧张素Ⅱ受体1抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 血管紧张素Ⅱ受体1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. 血管紧张素Ⅱ受体1抗体Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, 血管紧张素Ⅱ受体1抗体indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites.

血管紧张素Ⅱ受体1抗体Also known as:

AG2S; Agtr 1; Agtr1; AGTR1_HUMAN; Agtr1a; AGTR1B; Ang II; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; Angiotensin II type-1 receptor; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT 1r; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT1R; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; Type 1B angiotensin II receptor; Type-1 angiotensin II receptor.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from human AT2R C-terminus.

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血管紧张素Ⅱ受体1抗体Predicted Molecular Weight: 41kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl012Hu01S100钙结合蛋白(S100)多克隆抗体Polyclonal Antibody to S100 Calcium Binding Protein (S100)

kl012Mu01S100钙结合蛋白(S100)多克隆抗体Polyclonal Antibody to S100 Calcium Binding Protein (S100)

kl012Ra01S100钙结合蛋白(S100)多克隆抗体Polyclonal Antibody to S100 Calcium Binding Protein (S100)

kl013Cp01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Ga01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Hu01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Mu01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Po01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Ra01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Rb52骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl014Bo01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Ca01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Cp01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Ga01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Po01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Rb53骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl015Hu01骨成型蛋白受体1A(BMPR1A)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A)

kl015Mu01骨成型蛋白受体1A(BMPR1A)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A)

kl015Ra01骨成型蛋白受体1A(BMPR1A)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A)

kl017Bo01上皮性钙黏附蛋白(CDHE)多克隆抗体Polyclonal Antibody to Cadherin, Epithelial (CDHE)

kl017Ga01上皮性钙黏附蛋白(CDHE)多克隆抗体Polyclonal Antibody to Cadherin, Epithelial (CDHE)