视神经细胞相关蛋白/早老素结合蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml  视神经细胞相关蛋白/早老素结合蛋白抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

MOCA (modifier of cell adhesion), also known as Presenilin-binding protein (PBP) or dedicator of cytokinesis protein 3 (DOCK3), is a 2030 amino acid cytoplasmic protein belonging to the DOCK family. MOCA interacts with Presenilin proteins and has the ability to stimulate Tau phosphorylation suggesting that MOCA may be involved in Alzheimer disease. 视神经细胞相关蛋白/早老素结合蛋白抗体MOCA is also thought to be a guanine nucleotide exchange factor (GEF) which activates small GTPases by exchanging bound GDP for free GTP. Analysis of ectopic expression suggests that MOCA may affect the function of small GTPases involved in the regulation of Actin cytoskeleton or cell adhesion receptors. MOCA is localized to the neuropil, and sometimes in pyramidal cells, in normal brains, while in Alzheimer disease brains, MOCA is present in neurofibrillary tangles.

视神经细胞相关蛋白/早老素结合蛋白抗体Also known as:

Dedicator of cytokinesis protein 3; DOCK 3; MOCA; Modifier of cell adhesion; Presenilin binding protein; DOCK3_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,视神经细胞相关蛋白/早老素结合蛋白抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Rabbit, .

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Immunogen: KLH conjugated synthetic peptide derived from human DOCK3 (1.

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Predicted Molecular Weight: 233kDa.

Storage:

视神经细胞相关蛋白/早老素结合蛋白抗体Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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