DENND5B蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml DENND5B蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

DENND5B is a 1,274 amino acid single-pass membrane protein containing a dDENN domain, a DENN domain, a PLAT domain, two RUN domains and an uDENN domain. Existing as four alternatively spliced isoforms, DENND5B is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, DENND5B蛋白抗体achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. DENND5B蛋白抗体Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.

Also known as:

DENND5B蛋白抗体DENN domain containing protein 5B; DENN MADD domain containing 5B; Dennd5b; DEN5B_HUMAN； Rab6IP1 like protein.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Chicken, Cow, Horse, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human DENND5B.

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DENND5B蛋白抗体Predicted Molecular Weight: 145kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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