表皮生长因子样重复折叠1结构域蛋白3抗体

Quantity size:

0.2ml

Concentration:

1mg/ml  表皮生长因子样重复折叠1结构域蛋白3抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

EDIL3 is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3; also Del-1 and integrin-binding DEL1) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. Human EDIL3 is synthesized as a precursor with a 16 amino acid (aa) signal sequence and a 464 aa 表皮生长因子样重复折叠1结构域蛋白3抗体mature chain (SwissProt # O43854). The mature chain is composed of three epidermal growth factor (EGF) repeats and two discoidin-I-like domains. The second EGF repeat contains an RGD motif. Splicing variants produce two isoforms for human EDIL3. Isoform 2 has an A -> G substitution at aa 66 and a deletion of aa 67-76 found in isoform 1. Mature human EDIL3 shares 96% aa sequence identity with mature mouse EDIL3. The RGD motif of EDIL3 binds alpha v beta 5 integrin, which, in turn, leads to increased angiogenic transcription factor HoxD3 expression. HoxD3 activates alpha v beta 3 and uPA, resulting in the transformation of resting endothelial cells to an angiogenic state. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. It has been found, however, re-expressed in a number of human tumors as well表皮生长因子样重复折叠1结构域蛋白3抗体 as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. Exogenous application of EDIL3 has been demonstrated to augment angiogenesis and improve blood flow and tissue function in murine models of hind-limb ischemia, cardiac ischemia and cerebral ischemia. EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion.

表皮生长因子样重复折叠1结构域蛋白3抗体Also known as:

DEL1; Developmental endothelial locus 1; Developmentally regulated endothelial cell locus 1 protein; EGF like repeat and discoidin I like domain containing protein 3; EGF like repeats and discoidin I like domains protein 3; Integrin binding protein DEL1; EDIL3_HUMAN.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, ,Xenopuslaevis,Zebrafish.

●

Immunogen: KLH conjugated synthetic peptide derived from human EDIL3.

●

表皮生长因子样重复折叠1结构域蛋白3抗体Predicted Molecular Weight: 52kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl043Hu01肾上腺髓质素受体(AMR)多克隆抗体Polyclonal Antibody to Adrenomedullin Receptor (AMR)

kl045Hu01G蛋白偶联雌激素受体1(GPER)多克隆抗体Polyclonal Antibody to G Protein Coupled Estrogen Receptor 1 (GPER)

kl077Hu01嘌呤能受体P2X7(P2RX7)多克隆抗体Polyclonal Antibody to Purinergic Receptor P2X, Ligand Gated Ion Channel 7 (P2RX7)

kl122Hu01淀粉样蛋白β前体样蛋白2(APLP2)多克隆抗体Polyclonal Antibody to Amyloid Beta Precursor Like Protein 2 (APLP2)

kl150Hu01组氨酸丰富钙结合蛋白(HRC)多克隆抗体Polyclonal Antibody to Histidine Rich Calcium Binding Protein (HRC)

kl151Hu01天冬氨酸β羟化酶(ASPH)多克隆抗体Polyclonal Antibody to Askltate Beta Hydroxylase (ASPH)

kl152Hu01小泛素相关修饰蛋白2(SUMO2)多克隆抗体Polyclonal Antibody to Small Ubiquitin Related Modifier Protein 2 (SUMO2)

kl168Mu01Discs大同源物4(DLG4)多克隆抗体Polyclonal Antibody to Discs, Large Homolog 4 (DLG4)

kl168Ra01Discs大同源物4(DLG4)多克隆抗体Polyclonal Antibody to Discs, Large Homolog 4 (DLG4)

kl183Hu01胞质分裂作用因子3(DOCK3)多克隆抗体Polyclonal Antibody to Dedicator Of Cytokinesis 3 (DOCK3)

kl186Mu01Podocan蛋白(PODN)多克隆抗体Polyclonal Antibody to Podocan (PODN)

kl187Hu01酮戊二酸脱氢酶(OGDH)多克隆抗体Polyclonal Antibody to Oxoglutarate Dehydrogenase (OGDH)

kl191Hu01N-乙酰转移酶1(NAT1)多克隆抗体Polyclonal Antibody to N-Acetyltransferase 1 (NAT1)

kl191Mu01N-乙酰转移酶1(NAT1)多克隆抗体Polyclonal Antibody to N-Acetyltransferase 1 (NAT1)

kl198Hu01钙同线蛋白2(CLSTN2)多克隆抗体Polyclonal Antibody to Calsyntenin 2 (CLSTN2)

kl200Hu01上皮基质相互作用蛋白1(EPSTI1)多克隆抗体Polyclonal Antibody to Epithelial Stromal Interaction 1, Breast (EPSTI1)

kl208Mu01叉头框蛋白A2(FOXA2)多克隆抗体Polyclonal Antibody to Forkhead Box Protein A2 (FOXA2)

kl236Hu01酰基甘油激酶(AGK)多克隆抗体Polyclonal Antibody to Acylglycerol Kinase (AGK)

kl239Hu01外生骨疣蛋白1(EXT1)多克隆抗体Polyclonal Antibody to Exostoses 1 (EXT1)

kl246Hu01蛋白聚糖4(PRG4)多克隆抗体Polyclonal Antibody to Proteoglycan 4 (PRG4)