磷酸化HER3抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化HER3抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.磷酸化HER3抗体 Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital磷酸化HER3抗体 contracture syndrome type 2 (LCCS2); also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.

Also known as:

Her3/ErbB3(phospho-Tyr1276); p-HRE3 (Tyr1276); ErbB 3 (phospho Y1276); ERBB3; c erbB 3; c erbB3; ERBB3 protein; erbB3 S; Glial growth factor receptor; HER 3; HER3; LCCS2; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-like protein c ErbB 3; proto-oncogene-like 磷酸化HER3抗体protein c ErbB3; receptor tyrosine protein kinase ERB3; Receptor tyrosine protein kinase erbB 3; Receptor tyrosine protein kinase erbB3; Tyrosine kinase type cell surface receptor HER3; ERBB3_HUMAN.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Dog, Pig, Cow, Horse, .

●

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human.

●

磷酸化HER3抗体Predicted Molecular Weight: 148kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:20-530  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl471Hu01间隙连接蛋白26(CX26)多克隆抗体Polyclonal Antibody to Connexin 26 (CX26)

kl477Hu01基质Gla蛋白(MGP)多克隆抗体Polyclonal Antibody to Matrix Gla Protein (MGP)

kl477Ra01基质Gla蛋白(MGP)多克隆抗体Polyclonal Antibody to Matrix Gla Protein (MGP)

kl479Hu01肝素结合性表皮生长因子(HBEGF)多克隆抗体Polyclonal Antibody to Heklin Binding Epidermal Growth Factor Like Growth Factor (HBEGF)

kl479Mu01肝素结合性表皮生长因子(HBEGF)多克隆抗体Polyclonal Antibody to Heklin Binding Epidermal Growth Factor Like Growth Factor (HBEGF)

kl479Ra01肝素结合性表皮生长因子(HBEGF)多克隆抗体Polyclonal Antibody to Heklin Binding Epidermal Growth Factor Like Growth Factor (HBEGF)

kl480Hu01甘露糖结合蛋白(MBL)多克隆抗体Polyclonal Antibody to Mannose Binding Lectin (MBL)

kl480Mu01甘露糖结合蛋白(MBL)多克隆抗体Polyclonal Antibody to Mannose Binding Lectin (MBL)

kl481Hu01神经钙黏蛋白(CDH2)多克隆抗体Polyclonal Antibody to Cadherin, Neuronal (CDH2)

kl482Hu01唾液淀粉酶α1(AMY1)多克隆抗体Polyclonal Antibody to Amylase Alpha 1, Salivary (AMY1)

kl483Hu01胰弹性蛋白酶(ELA1)多克隆抗体Polyclonal Antibody to Elastase 1, klcreatic (ELA1)

kl483Mu01胰弹性蛋白酶(ELA1)多克隆抗体Polyclonal Antibody to Elastase 1, klcreatic (ELA1)

kl486Hu01钙网蛋白(CRT)多克隆抗体Polyclonal Antibody to Calreticulin (CRT)

kl486Mu01钙网蛋白(CRT)多克隆抗体Polyclonal Antibody to Calreticulin (CRT)

kl486Ra01钙网蛋白(CRT)多克隆抗体Polyclonal Antibody to Calreticulin (CRT)

kl488Hu01趋化因子C-X-C-基元受体7(CXCR7)多克隆抗体Polyclonal Antibody to Chemokine C-X-C-Motif Receptor 7 (CXCR7)

kl492Bo01鸟氨酸氨基甲酰转移酶(OCT)多克隆抗体Polyclonal Antibody to Ornithine Carbamoyl Transferase (OCT)

kl492Hu01鸟氨酸氨基甲酰转移酶(OCT)多克隆抗体Polyclonal Antibody to Ornithine Carbamoyl Transferase (OCT)

kl492Ra01鸟氨酸氨基甲酰转移酶(OCT)多克隆抗体Polyclonal Antibody to Ornithine Carbamoyl Transferase (OCT)

kl494Hu01纤调蛋白(FMOD)多克隆抗体Polyclonal Antibody to Fibromodulin (FMOD)

kl494Ra01纤调蛋白(FMOD)多克隆抗体Polyclonal Antibody to Fibromodulin (FMOD)

kl495Bo01山梨醇脱氢酶(SDH)多克隆抗体Polyclonal Antibody to Sorbitol Dehydrogenase (SDH)

kl495Hu01山梨醇脱氢酶(SDH)多克隆抗体Polyclonal Antibody to Sorbitol Dehydrogenase (SDH)

kl495Ra01山梨醇脱氢酶(SDH)多克隆抗体Polyclonal Antibody to Sorbitol Dehydrogenase (SDH)

kl496Hu01基膜聚糖(LUM)多克隆抗体Polyclonal Antibody to Lumican (LUM)