叉头蛋白O1/O3/O4抗体

Quantity size:

0.2ml

Concentration:

1mg/ml  叉头蛋白O1/O3/O4抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein.叉头蛋白O1/O3/O4抗体 The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. 叉头蛋白O1/O3/O4抗体It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.

叉头蛋白O1/O3/O4抗体Also known as:

AFX1; FOXO1+FOXO3+FOXO4; FKH1; FKHRL1; FKHRL1P2; Forkhead box O1; Forkhead box O3; Forkhead box O4; FOXO1; FOXO2; FOXO3; FOXO4; MLLT7; FOXO1_HUMAN; FOXO3_HUMAN; FOXO4_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human FOXO1/FO.

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叉头蛋白O1/O3/O4抗体Predicted Molecular Weight: 70kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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