范可尼综合征相关蛋白FANCC抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 范可尼综合征相关蛋白FANCC抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromsomal instability (1,2). The FA Group C complementation group gene encodes the protein FANCC, which is located in both cytoplasmic and nuclear compartments. FANCC is expressed in a cell cycle-dependent manner, with the lowest levels at 范可尼综合征相关蛋白FANCC抗体the G1/S boundary and the highest levels in the M-phase. The FANCC protein interacts with other FA complementation group proteins as well as non-FA proteins (3). A human a spectrin II (designated aSpIIs) acts as a scaffold to enhance interactions between FANCC and FANCA to form a nuclear 范可尼综合征相关蛋白FANCC抗体complex (4,5). Another binding partner of FANCC is the BTB/POZ domain containing protein FAZF, which is a transcriptional repressor (6). In hematopoietic cells expressing mutant FANCC, PKR is constitutively phosphorylated and has increased binding affinity for double-stranded RNA (7,8), which suggests that FANCC indirectly suppresses the activity of PKR. These cells are also apoptotic and are hypersensitive to IFNg and TNFa (8). In addition, FANCC protein is involved in the activation of STAT1 through receptors for at least three hematopoietic growth and survival factors (8).

范可尼综合征相关蛋白FANCC抗体Also known as:

bA80I15.1; FA 3; FA3; FAC; FACC; FANCC; FANCC_HUMAN; Fanconi anemia complementation group C; Fanconi anemia complementation group C protein; Fanconi anemia group C protein; Fanconi pancytopenia type 3; FLJ14675; Protein FACC.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Dog, Horse, .

●

Immunogen: KLH conjugated synthetic peptide derived from human FANCC.

●

Predicted Molecular Weight: 63kDa.

范可尼综合征相关蛋白FANCC抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl593Mu01淋巴细胞抗原75(LY75)多克隆抗体Polyclonal Antibody to Lymphocyte Antigen 75 (LY75)

kl595Hu01酪氨酸激酶2(Tyk2)多克隆抗体Polyclonal Antibody to Tyrosine Kinase 2 (Tyk2)

kl598Hu01干扰素调节因子5(IRF5)多克隆抗体Polyclonal Antibody to Interferon Regulatory Factor 5 (IRF5)

kl601Hu01B-淋巴细胞趋化因子1(BLC1)多克隆抗体Polyclonal Antibody to B-Lymphocyte Chemoattractant 1 (BLC1)

kl602Hu01C-型凝集素域家族4成员K(CLEC4K)多克隆抗体Polyclonal Antibody to C-Type Lectin Domain Family 4, Member K (CLEC4K)

kl603Hu01生长调节致癌基因β(GROβ)多克隆抗体Polyclonal Antibody to Growth Regulated Oncogene Beta (GROb)

kl604Hu01生长调节致癌基因γ(GROγ)多克隆抗体Polyclonal Antibody to Growth Regulated Oncogene Gamma (GROg)

kl607Hu01胸肾表达趋化因子(BRAK)多克隆抗体Polyclonal Antibody to Breast And Kidney Expressed Chemokine (BRAK)

kl607Mu01胸肾表达趋化因子(BRAK)多克隆抗体Polyclonal Antibody to Breast And Kidney Expressed Chemokine (BRAK)

kl608Hu01核受体亚家族3C组成员1(NR3C1)多克隆抗体Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1)

kl608Ra01核受体亚家族3C组成员1(NR3C1)多克隆抗体Polyclonal Antibody to Nuclear Receptor Subfamily 3, Group C, Member 1 (NR3C1)

kl611Hu01神经氨酸酶(NEU)多克隆抗体Polyclonal Antibody to Neuraminidase (NEU)

kl612Hu01绒毛膜促性腺激素α肽(CGα)多克隆抗体Polyclonal Antibody to Chorionic Gonadotropin Alpha Polypeptide (CGa)

kl613Mu01凝血因子ⅩⅢB肽(F13B)多克隆抗体Polyclonal Antibody to Coagulation Factor XIII B Polypeptide (F13B)

kl620Hu01C4结合蛋白α(C4BPα)多克隆抗体Polyclonal Antibody to C4 Binding Protein Alpha (C4BPa)

kl622Hu01表面活性物质关联蛋白B(SPB)多克隆抗体Polyclonal Antibody to Surfactant Associated Protein B (SPB)

kl622Ra01表面活性物质关联蛋白B(SPB)多克隆抗体Polyclonal Antibody to Surfactant Associated Protein B (SPB)

kl623Hu01表面活性物质关联蛋白C(SPC)多克隆抗体Polyclonal Antibody to Surfactant Associated Protein C (SPC)

kl623Ra01表面活性物质关联蛋白C(SPC)多克隆抗体Polyclonal Antibody to Surfactant Associated Protein C (SPC)

kl624Mu01胞浆型磷脂酶A2(cPLA2)多克隆抗体Polyclonal Antibody to Phospholikle A2, Cytosolic (cPLA2)