磷酸化G蛋白偶联受体激酶相互作用蛋白1

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化G蛋白偶联受体激酶相互作用蛋白1  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate 磷酸化G蛋白偶联受体激酶相互作用蛋白1cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).

磷酸化G蛋白偶联受体激酶相互作用蛋白1Also known as:

GIT1 (phospho Y545); p-GIT1 (phospho-Y545); ARF GAP GIT1; ARF GTPase activating protein GIT1; CAT 1; Cat1; Cool associated and tyrosine phosphorylated protein 1; G protein coupled receptor kinase interactor 1; GRK interacting protein 1.

Specificity:

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Rabbit Polyclonal IgG,磷酸化G蛋白偶联受体激酶相互作用蛋白1 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Pig, Cow, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human.

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Predicted Molecular Weight: 84kDa.

磷酸化G蛋白偶联受体激酶相互作用蛋白1Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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