蛋白转运抑制剂GBF1抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 蛋白转运抑制剂GBF1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Protein trafficking to the membrane requires formation of coated carrier vesicles, such as COPI-coated vesicles from the cis-golgi, a process triggered by membrane binding of the GTP-bound form of ADP-ribosylation factors. Normally, brefeldin A (BFA) blocks this action by inhibiting guanine nucleotide exchange factors (GEFs) for ADP-ribosylation factor.蛋白转运抑制剂GBF1抗体 However, GBF1, a member of the sec7-domain family of GEFs, allows cells to maintain normal golgi morphology and grow in the presence of BFA. The gene encoding the human GBF1 protein maps to chromosome 10q24, with the sec7-domain centrally positioned, and a proline-rich C-terminus. Based on mutatagenesis analysis, this proline rich region appears to interact with p115 in a functionally significant manner.

蛋白转运抑制剂GBF1抗体Also known as:

ARF1GEF; BFA resistant GEF 1; BFA-resistant GEF 1; FLJ21263; FLJ21500; GBF1; GBF1_HUMAN; Golgi specific brefeldin A resistance factor 1; Golgi specific Brefeldin A-resistance factor; Golgi-specific brefeldin A-resistance guanine nucleotide exchange; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; KIAA0248; MGC134877; MGC134878.

Specificity:

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Rabbit Polyclonal IgG, 蛋白转运抑制剂GBF1抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human Brefeldi.

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Predicted Molecular Weight: 206kDa.

蛋白转运抑制剂GBF1抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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