G蛋白偶联受体40抗体

Quantity size:

0.2ml

Concentration:

1mg/ml G蛋白偶联受体40抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

G protein coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G protein-coupled receptor 40 (GPR40) functions as a cell-surface receptor for long-chain free fatty acids (FFAs). FFAs provide an important energy source, but also function as signaling molecules in variousG蛋白偶联受体40抗体 pathways, notably the process of insulin secretion. In pancreatic tissue, the interaction of long chain FFAs with GPR40 amplifies glucose-stimulated insulin secretion from beta cells, suggesting a possible role for GPR40 in the treatment of diabetes associated with insulin-deficiency. Specifically, the Arg211His polymorphism in the GPR40 gene may contribute to the variation G蛋白偶联受体40抗体of insulin secretory capacity in Japanese men. Also, GPR40 may be involved in the control of breast cancer cell growth by fatty acids and, therefore, provide a link between fat and cancer.

G蛋白偶联受体40抗体Also known as:

GPCR GPR40; FFA1R; FFAR 1; FFAR1; Free fatty acid receptor 1; G protein coupled receptor 40; GPR 40; FFAR1_HUMAN; GPCR40.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, .

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Immunogen: KLH conjugated synthetic peptide derived from human G protei.

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G蛋白偶联受体40抗体Predicted Molecular Weight: 33kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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