生长因子受体结合蛋白2相关蛋白3抗体

Quantity size:

0.2ml

Concentration:

1mg/ml生长因子受体结合蛋白2相关蛋白3抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (1–3). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation,生长因子受体结合蛋白2相关蛋白3抗体 proliferation and differentiation occur (1–3). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the生长因子受体结合蛋白2相关蛋白3抗体 cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5).

Also known as:

Gab3; GAB3_HUMAN; GRB2-associated binder 3; GRB2-associated-binding protein 3; Growth factor receptor bound protein 2-associated protein 3.

Specificity:

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Rabbit Polyclonal IgG,生长因子受体结合蛋白2相关蛋白3抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human GAB3.

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Predicted Molecular Weight: 66kDa.

生长因子受体结合蛋白2相关蛋白3抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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