ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体

Quantity size:

0.2ml

Concentration:

1mg/ml ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体(GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin ∫1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells.

ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体Also known as:

ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARF GEP100; ARFGEP100; BRAG2; Brefeldin A resistant ARF GEF2; Brefeldin-resistant Arf-GEF 2 protein; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; IQEC1_HUMAN; Iqsec1; Kiaa0763.

Specificity:

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Rabbit Polyclonal IgG,ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human GEP100.

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Predicted Molecular Weight: 108kDa.

ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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