缺氧诱导因子2α /HIF-2α/HIF-2-alpha抗体

Quantity size:

0.2ml

Concentration:

1mg/ml缺氧诱导因子2α /HIF-2α/HIF-2-alpha抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to 缺氧诱导因子2α /HIF-2α/HIF-2-alpha抗体be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

缺氧诱导因子2α /HIF-2α/HIF-2-alpha抗体Also known as:

Hypoxia-inducible factor -2 alpha; HIF 2 Alpha; HIF2 Alpha; HIF 2; HIF2A; AHypoxia-inducible factor 2 alpha; HIF-2 alpha; Endothelial PAS domain-containing protein 1; EPAS-1; HIF-1 alpha-like factor; MHLF; HIF-related factor; HRF; MOP2; Hif2a.

Specificity:

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Rabbit Polyclonal IgG, 缺氧诱导因子2α /HIF-2α/HIF-2-alpha抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Pig, Cow, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from mouse HIF 2 Al.

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缺氧诱导因子2α /HIF-2α/HIF-2-alpha抗体Predicted Molecular Weight: 96kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:20-300  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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