人乳头瘤病毒16型L2抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 人乳头瘤病毒16型L2抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Human papillomaviruses, particularly type 16 (designated HPV16), infect the genital tract and may lead to cervical cancer. Protection against HPV16 is thought to be provided by neutralizing antibodies directed to the major caspid protein L1 of HPV16. HPV16 L1 forms the pentameric assembly unit of the viral shell, and the binding of HPV16 L1 to the cell 人乳头瘤病毒16型L2抗体surface without the involvement of minor capsid protein L2 is believed to be the first step of HPV16 infection. The L1-binding domain located near the C-terminus of L2 binds L1 prior to completion of capsid assembly and is required for efficient encapsidation of the viral genome. In addition, the C-terminus of L1 is necessary for both DNA binding and DNA packaging. Expression of the late gene L1 is restricted to the upper layers of the infected epithelium. HPV16 L1 is able to package unrelated plasmid DNA in vitro and deliver the foreign DNA 人乳头瘤病毒16型L2抗体to eukaryotic cells with the subsequent expression of the encoded gene. L1 shows a diffuse nuclear distribution whereas L2 is localized to punctate nuclear regions identified as promonocytic leukemia protein oncogenic domains (PODs). Coexpression of L1 and L2 induces a relocalization of L1 into the PODs.

人乳头瘤病毒16型L2抗体Also known as:

HPV16 L2; HPV16-L2; HPV-16; HPV-16 capsid; HPV16 capsid protein; HPV16 major capsid protein L2; Human papillomavirus type 16 L2; Human papillomavirus type 16 major capsid protein L2; Major capsid L2 protein; Major capsid protein; Major capsid protein L2; VL2_HPV16.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: HPV16.

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Immunogen: KLH conjugated synthetic peptide derived from HPV16 L2.

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人乳头瘤病毒16型L2抗体Predicted Molecular Weight: 52kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:50-200   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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