遗传性血色病蛋白相关蛋白1抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 遗传性血色病蛋白相关蛋白1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular 遗传性血色病蛋白相关蛋白1抗体localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells:遗传性血色病蛋白相关蛋白1抗体 inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.

Also known as:

dJ221C16.10.1; Hemochromatosis; Hemochromatosis protein; Hereditary hemochromatosis protein; Hereditary hemochromatosis protein HLA H; HFE 1; HFE; HFE_HUMAN; HFE1; HH; High Fe; HLA H; HLA-H; HLAH; 遗传性血色病蛋白相关蛋白1抗体MGC:150812; MGC10379; MGC103790; MHC class I like protein HFE; MVCD7; TFQTL2.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, .

●

Immunogen: KLH conjugated synthetic peptide derived from Human HFE/Hemo.

●

遗传性血色病蛋白相关蛋白1抗体Predicted Molecular Weight: 38kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:20-100  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl819Hu01甲状旁腺激素相关蛋白(PTHrP)多克隆抗体Polyclonal Antibody to klathyroid Hormone Related Protein (PTHrP)

kl819Mu01甲状旁腺激素相关蛋白(PTHrP)多克隆抗体Polyclonal Antibody to klathyroid Hormone Related Protein (PTHrP)

kl819Ra01甲状旁腺激素相关蛋白(PTHrP)多克隆抗体Polyclonal Antibody to klathyroid Hormone Related Protein (PTHrP)

kl822Ga0160kD热休克蛋白(HSPD1)多克隆抗体Polyclonal Antibody to Heat Shock 60kD Protein 1, Chaperonin (HSPD1)

kl822Hu0160kD热休克蛋白(HSPD1)多克隆抗体Polyclonal Antibody to Heat Shock 60kD Protein 1, Chaperonin (HSPD1)

kl822Mu0160kD热休克蛋白(HSPD1)多克隆抗体Polyclonal Antibody to Heat Shock 60kD Protein 1, Chaperonin (HSPD1)

kl822Ra0160kD热休克蛋白(HSPD1)多克隆抗体Polyclonal Antibody to Heat Shock 60kD Protein 1, Chaperonin (HSPD1)

kl823Bo0190kDa热休克蛋白β1(HSP90β1)多克隆抗体Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1)

kl823Hu0190kDa热休克蛋白β1(HSP90β1)多克隆抗体Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1)

kl823Mu0190kDa热休克蛋白β1(HSP90β1)多克隆抗体Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1)

kl823Ra0190kDa热休克蛋白β1(HSP90β1)多克隆抗体Polyclonal Antibody to Heat Shock Protein 90kDa Beta 1 (HSP90b1)

kl824Hu01B-淋巴细胞激活抗原B7-2(LAB7-2)多克隆抗体Polyclonal Antibody to B-Lymphocyte Activation Antigen B7-2 (LAB7-2)

kl827Mu01肿瘤坏死因子配体超家族成员14(TNFSF14)多克隆抗体Polyclonal Antibody to Tumor Necrosis Factor Ligand Superfamily, Member 14 (TNFSF14)

kl829Hu01免疫球蛋白G3(IgG3)多克隆抗体Polyclonal Antibody to Immunoglobulin G3 (IgG3)

kl833Ca01血管性血友病因子(vWF)多克隆抗体Polyclonal Antibody to Von Willebrand Factor (vWF)

kl833Po01血管性血友病因子(vWF)多克隆抗体Polyclonal Antibody to Von Willebrand Factor (vWF)

kl833Rb51血管性血友病因子(vWF)多克隆抗体Polyclonal Antibody to Von Willebrand Factor (vWF)

kl834Hu01凝血因子Ⅹ(F10)多克隆抗体Polyclonal Antibody to Coagulation Factor X (F10)

kl834Mu01凝血因子Ⅹ(F10)多克隆抗体Polyclonal Antibody to Coagulation Factor X (F10)

kl834Ra01凝血因子Ⅹ(F10)多克隆抗体Polyclonal Antibody to Coagulation Factor X (F10)