毛皮质细胞角蛋白/细胞角蛋白40抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 毛皮质细胞角蛋白/细胞角蛋白40抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Keratin 40 (KRT40), also known as Cytokeratin-40 (CK-40) or KA36, is a 431 amino acid protein that belongs to the intermediate filament family. As a heterotetramer of two type I and two type II keratins, Keratin 40 may play a role in late hair differentiation. While weakly expressed in tongue, breast, colon and small intestine, Keratin 40 is highly 毛皮质细胞角蛋白/细胞角蛋白40抗体expressed in skin and scalp. The gene that encodes Keratin 40 consists of approximately 9,420 bases and maps to human chromosome 17q21.2. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is 毛皮质细胞角蛋白/细胞角蛋白40抗体associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes.

毛皮质细胞角蛋白/细胞角蛋白40抗体Also known as:

CK-40; Cytokeratin-40; Cytokeratin40; K1C40_HUMAN; Cytokeratin 40; Keratin, type I cytoskeletal 40; Keratin-40; KRT40; Type I hair keratin Ka36.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Dog, Cow, Horse, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human hair cor.

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毛皮质细胞角蛋白/细胞角蛋白40抗体Predicted Molecular Weight: 48kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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