热休克蛋白104抗体

Quantity size:

0.2ml

Concentration:

1mg/ml热休克蛋白104抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Hsp104 is a molecular chaperone required for stress tolerance and for maintenance of [psi(+)] prions in the budding yeast Saccharomyces cerevisiae (1,2). HSP104 is a hexameric protein with two AAA ATPase domains (N- and C-terminal nucleotide-binding domains NBD1 and NBD2, respectively) per monomer (3). NBD1 and NBD2 have very different catalytic properties, 热休克蛋白104抗体but each shows positive cooperativity in hydrolysis (3,4). Point mutations in either of the two nucleotide-binding domains (NBD) of Hsp104 (NBD1 and NBD2) eliminate its thermotolerance function in vivo (5). Hsp104 interacts with Hsp90 cochaperones in respiring yeast (1). The primary热休克蛋白104抗体 function of Hsp104 in prion propagation is to disassemble prion aggregates and generate the small prion seeds that initiate new rounds of prion propagation (possibly assisted by Hsp70-Ssa) (6).

Also known as:

热休克蛋白104抗体L0948; Heat shock protein 104; HS104_YEAST; Hsp 104.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Saccharomyces cerevisiae.

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Immunogen: KLH conjugated synthetic peptide derived from human Hsp104.

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热休克蛋白104抗体Predicted Molecular Weight: 102kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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