胰岛素受体抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 胰岛素受体抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The insulin receptor is a heterotetrameric membrane glycoprotein with tyrosine-protein kinase activity, consisting of disulfide-linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit possesses a single transmembrane domain, whereas the alpha subunit is completely extracellular. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Binding of insulin to 胰岛素受体抗体the insulin receptor stimulates its association with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K) which leads to glucose uptake. Two transcript variants encoding different isoforms have been found for this gene produced by alternative splicing.

胰岛素受体抗体Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine胰岛素受体抗体 (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Also known as:

CD 220; CD220; CD220 antigen; HHF 5; HHF5; INSR; IR; INSR_HUMAN; Insulin receptor subunit alpha.

Specificity:

●

胰岛素受体抗体Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, .

●

Immunogen: KLH conjugated synthetic peptide derived from human Insulin .

●

Predicted Molecular Weight: 80/165kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:20-300  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl457Mu01胱天蛋白酶14(CASP14)多克隆抗体Polyclonal Antibody to Caskle 14 (CASP14)

kl457Ra01胱天蛋白酶14(CASP14)多克隆抗体Polyclonal Antibody to Caskle 14 (CASP14)

kl464Hu01盐皮质激素受体(MR)多克隆抗体Polyclonal Antibody to Mineralocorticoid Receptor (MR)

kl464Ra01盐皮质激素受体(MR)多克隆抗体Polyclonal Antibody to Mineralocorticoid Receptor (MR)

kl468Hu01衰变加速因子(DAF)多克隆抗体Polyclonal Antibody to Decay Accelerating Factor (DAF)

kl470Hu01热休克转录因子2(HSF2)多克隆抗体Polyclonal Antibody to Heat Shock Transcription Factor 2 (HSF2)

kl471Bo01骨钙素(OC)多克隆抗体Polyclonal Antibody to Osteocalcin (OC)

kl471Ca01骨钙素(OC)多克隆抗体Polyclonal Antibody to Osteocalcin (OC)

kl471Hu01骨钙素(OC)多克隆抗体Polyclonal Antibody to Osteocalcin (OC)

kl471Mu01骨钙素(OC)多克隆抗体Polyclonal Antibody to Osteocalcin (OC)

kl471Po01骨钙素(OC)多克隆抗体Polyclonal Antibody to Osteocalcin (OC)

kl471Ra01骨钙素(OC)多克隆抗体Polyclonal Antibody to Osteocalcin (OC)

kl471Rb51骨钙素(OC)多克隆抗体Polyclonal Antibody to Osteocalcin (OC)

kl472Ca01降钙素(CT)多克隆抗体Polyclonal Antibody to Calcitonin (CT)

kl472Hu01降钙素(CT)多克隆抗体Polyclonal Antibody to Calcitonin (CT)

kl472Mu01降钙素(CT)多克隆抗体Polyclonal Antibody to Calcitonin (CT)

kl472Ra01降钙素(CT)多克隆抗体Polyclonal Antibody to Calcitonin (CT)

kl491Hu01角蛋白2(KRT2)多克隆抗体Polyclonal Antibody to Keratin 2 (KRT2)

kl492Hu01角蛋白1(KRT1)多克隆抗体Polyclonal Antibody to Keratin 1 (KRT1)

kl500Hu01嵌套蛋白(NES)多克隆抗体Polyclonal Antibody to Nestin (NES)

kl512Hu01纤维介素蛋白(FGL2)多克隆抗体Polyclonal Antibody to Fibrinogen Like Protein 2 (FGL2)

kl512Mu01纤维介素蛋白(FGL2)多克隆抗体Polyclonal Antibody to Fibrinogen Like Protein 2 (FGL2)

kl514Hu01失调蛋白1(ATXN1)多克隆抗体Polyclonal Antibody to Ataxin 1 (ATXN1)