白介素2受体γ链抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 白介素2受体γ链抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), 白介素2受体γ链抗体and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. 
In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, 白介素2受体γ链抗体and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. 
The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade白介素2受体γ链抗体. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement. Mutation of IL2R gamma has been determined to be the cause of severe X-linked combined immunodeficiency (X SCID), a disease that is characterized by the absence of T cells and NK cells.

白介素2受体γ链抗体Also known as:

IL2 Receptor gamma; IL2R gamma; IL 2R gamma; IL-2R gamma; IL-2 receptor gamma precursor; IL2 Receptor gamma; CD132; CD 132; common cytokine receptor gamma chain; Gamma C; gamma(c); IL-2R gamma chain; IL2RG; IMD4; interleukin 2 receptor, gamma; P64; SCIDX; SCIDX1; Cytokine receptor common subunit gamma; Gamma C; gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL-2RG; IL2RG_HUMAN; Interleukin-2 receptor subunit gamma; p64; SCIDX; SCIDX1.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, .

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Immunogen: KLH conjugated synthetic peptide derived from human IL-2R ga.

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Predicted Molecular Weight: 41kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:20-500  IF=1:100-500 

kl059Cp01白介素12A(IL12A)多克隆抗体Polyclonal Antibody to Interleukin 12A (IL12A)

kl059Eq01白介素12A(IL12A)多克隆抗体Polyclonal Antibody to Interleukin 12A (IL12A)

kl059Ga01白介素12A(IL12A)多克隆抗体Polyclonal Antibody to Interleukin 12A (IL12A)

kl059Hu01白介素12A(IL12A)多克隆抗体Polyclonal Antibody to Interleukin 12A (IL12A)

kl059Mu01白介素12A(IL12A)多克隆抗体Polyclonal Antibody to Interleukin 12A (IL12A)

kl059Po01白介素12A(IL12A)多克隆抗体Polyclonal Antibody to Interleukin 12A (IL12A)

kl059Ra01白介素12A(IL12A)多克隆抗体Polyclonal Antibody to Interleukin 12A (IL12A)

kl060Bo01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Ca01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Cp01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Eq01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Ga01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Hu01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Mu01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Po01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Ra01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl060Si01白介素13(IL13)多克隆抗体Polyclonal Antibody to Interleukin 13 (IL13)

kl061Bo01白介素15(IL15)多克隆抗体Polyclonal Antibody to Interleukin 15 (IL15)

kl061Cp01白介素15(IL15)多克隆抗体Polyclonal Antibody to Interleukin 15 (IL15)

kl061Fi01白介素15(IL15)多克隆抗体Polyclonal Antibody to Interleukin 15 (IL15)

kl061Ga01白介素15(IL15)多克隆抗体Polyclonal Antibody to Interleukin 15 (IL15)