磷酸化胰岛素受体底物-1抗体

Quantity size:

0.1ml

Concentration:

1mg/ml磷酸化胰岛素受体底物-1抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation,磷酸化胰岛素受体底物-1抗体 although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

磷酸化胰岛素受体底物-1抗体Also known as:

p-IRS1; IRS1(phospho-Ser789); IRS1 (phospho S789); p-IRS1 (phospho S789); HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS-1; IRS 1; IRS1; OTTHUMP00000164234; IRS1_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, 磷酸化胰岛素受体底物-1抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human.

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Predicted Molecular Weight: 132kDa.

磷酸化胰岛素受体底物-1抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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