E3泛素蛋白连接酶144B/环指蛋白144B抗体

Quantity size:

0.2ml

Concentration:

1mg/ml E3泛素蛋白连接酶144B/环指蛋白144B抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosisE3泛素蛋白连接酶144B/环指蛋白144B抗体  via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Tissue specificity: Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.

E3泛素蛋白连接酶144B/环指蛋白144B抗体 Also known as:

E3 ubiquitin protein ligase RNF144B; RING finger protein 144B; E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain containing protein 2; IBR domain-containing protein 2; IBRDC 2; p53 inducible RING finger protein; p53-inducible RING finger protein;E3泛素蛋白连接酶144B/环指蛋白144B抗体  p53RFP; PIR2; R144B_HUMAN; Ring finger 144B; RING finger protein 144B; RNF 144B; RNF144B.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, Cat, .

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E3泛素蛋白连接酶144B/环指蛋白144B抗体 Immunogen: KLH conjugated synthetic peptide derived from human IBRDC2/R.

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Predicted Molecular Weight: 34kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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