激活素受体相互作用蛋白4抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 激活素受体相互作用蛋白4抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation. It is involved in the control of inflammatory signaling pathways. Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3,激活素受体相互作用蛋白4抗体 TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of the complex after TNF stimulation. Once the complex is formed, TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteosomal degradation and consequently termination of the TNF- or LPS-mediated activation of NFKB1. Ubiquitinates RIPK2 by 'Lys-63'-linked conjugation and influences NOD2-dependent signal transduction pathways. Regulates the transcriptional activity of several transcription factors, and probably plays an important role in the regulation of immune response. Ubiquitinates NFE2 by 'Lys-63' linkages and is implicated in the control of the development of hematopoietic lineages. Critical regulator of T helper (TH2) 激活素受体相互作用蛋白4抗体cytokine development through its ability to induce JUNB ubiquitination and degradation (By similarity). Ubiquitinates SNX9. Ubiquitinates CXCR4 and HGS/HRS and regulates sorting of CXCR4 to the degradative pathway. It is involved in the negative regulation of MAVS-dependent cellular antiviral responses. Ubiquitinates MAVS through 'Lys-48'-linked conjugation resulting in MAVS proteosomal degradation. Involved in the regulation of apoptosis and reactive oxygen species levels through the ubiquitination and proteosomal degradation of TXNIP. Mediates the antiapoptotic activity of epidermal growth factor through the ubiquitination and proteosomal degradation of p15 BID. Targets DTX1 for lysosomal degradation and controls NOTCH1 degradation, in the absence of ligand, through 'Lys-29'-linked polyubiquitination.

Also known as:

ADMFD; AIF4; AIP4; Atrophin 1 interacting protein 4; Atrophin-1-interacting protein 4; dJ468O1.1; dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)); dJ468O1.1 atrophin 1 interacting protein 4 AIP4; E3 ubiquitin protein ligase Itchy homolog; E3 ubiquitin-protein ligase Itchy激活素受体相互作用蛋白4抗体 homolog; EC 6.3.2; Itch; ITCH_HUMAN; Itchy E3 ubiquitin protein ligase; Itchy E3 ubiquitin protein ligase homolog; Itchy E3 ubiquitin protein ligase homolog mouse; Itchy E3 ubiquitin protein ligase, mouse, homolog of; Itchy homolog E3 ubiquitin protein ligase; Itchy mouse homolog E3 ubi

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, .

●

Immunogen: KLH conjugated synthetic peptide derived from human ITCH/AIP.

●

激活素受体相互作用蛋白4抗体Predicted Molecular Weight: 103kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 

l322Mu01自身免疫调节因子(AIRE)多克隆抗体Polyclonal Antibody to Autoimmune Regulator (AIRE)

kl323Hu01外核苷酸焦磷酸酶/磷酸二酯酶2(ENPP2)多克隆抗体Polyclonal Antibody to Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2)

kl324Hu01Bcl2拮抗/杀伤因子1(BAK1)多克隆抗体Polyclonal Antibody to Bcl2 Antagonist/Killer 1 (BAK1)

kl332Hu01核有丝分裂器蛋白1(NUMA1)多克隆抗体Polyclonal Antibody to Nuclear Mitotic Apklatus Protein 1 (NUMA1)

kl335Hu01Bcl2关联永生基因3(BAG3)多克隆抗体Polyclonal Antibody to Bcl2 Associated Athanogene 3 (BAG3)

kl340Hu01胱天蛋白酶6(CASP6)多克隆抗体Polyclonal Antibody to Caskle 6 (CASP6)

kl342Hu01胆盐依赖性脂肪酶(BSDL)多克隆抗体Polyclonal Antibody to Likle, Bile Salt Dependent (BSDL)

kl343Hu0170kDa热休克蛋白5(HSPA5)多克隆抗体Polyclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5)

kl343Mu0170kDa热休克蛋白5(HSPA5)多克隆抗体Polyclonal Antibody to Heat Shock 70kDa Protein 5 (HSPA5)

kl345Hu01膜联蛋白A6(ANXA6)多克隆抗体Polyclonal Antibody to Annexin A6 (ANXA6)

kl347Hu01嗜乳脂蛋白亚家族1成员A1(BTN1A1)多克隆抗体Polyclonal Antibody to Butyrophilin Subfamily 1, Member A1 (BTN1A1)

kl348Hu01丁酰胆碱酯酶(BCHE)多克隆抗体Polyclonal Antibody to Butyrylcholinesterase (BCHE)

kl353Hu01钙周期素结合蛋白(CACYBP)多克隆抗体Polyclonal Antibody to Calcyclin Binding Protein (CACYBP)

kl359Hu01钙磷蛋白(CAPS)多克隆抗体Polyclonal Antibody to Calcyphosine (CAPS)

kl363Hu01染色框同源物3(CBX3)多克隆抗体Polyclonal Antibody to Chromobox Homolog 3 (CBX3)

kl363Mu01染色框同源物3(CBX3)多克隆抗体Polyclonal Antibody to Chromobox Homolog 3 (CBX3)

kl368Hu01周期素依赖性激酶抑制因子3(CDKN3)多克隆抗体Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 3 (CDKN3)

kl369Hu01角化粒素(CDSN)多克隆抗体Polyclonal Antibody to Corneodesmosin (CDSN)

kl374Ra01羧酸酯酶1(CES1)多克隆抗体Polyclonal Antibody to Carboxylesterase 1 (CES1)

kl387Hu01夏科雷登氏结晶蛋白(CLC)多克隆抗体Polyclonal Antibody to Charcot Leyden Crystal Protein (CLC)

kl387Mu01夏科雷登氏结晶蛋白(CLC)多克隆抗体Polyclonal Antibody to Charcot Leyden Crystal Protein (CLC)

kl388Hu01封闭蛋白1(CLDN1)多克隆抗体Polyclonal Antibody to Claudin 1 (CLDN1)

kl389Hu01心营养素样细胞因子1(CLCF1)多克隆抗体Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1)

kl390Hu01氯化物细胞内通道蛋白1(CLIC1)多克隆抗体Polyclonal Antibody to Chloride Intracellular Channel Protein 1 (CLIC1)

kl393Hu01皮质醇稳定蛋白(CORT)多克隆抗体Polyclonal Antibody to Cortistatin (CORT)