Intersectin 2抗体

Quantity size:

0.1ml

Concentration:

1mg/mlIntersectin 2抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Intersectin, which is also designated Ese1 or ITSN1, is a component of the cellular endocytic machinery. Intersectin is composed of two N-terminal Ese15 homology (EH) domains, a central highly charged region and five C-terminal SH3 domains, which all largely contribute to the association of Intersectin with other components of the endocytic pathway. The EH domainIntersectin 2抗体 is particularly responsible for the directed localization of Intersectin to Clathrin-coated pits near the plasma membrane. Within the endocytic vesicles the SH3 domains facilitate the binding of Intersectin with Dynamin, and the central domain is essential for the association of Intersectin with SNAP 25. Two isoforms of Intersectin are produced as a result of alternative splicing in a stop codon, and they are designated as Intersectin-short and long (or IntersectinS and IntersectinL) to reflect an extended C-terminal domain. The long form, which has Intersectin 2抗体an extended C-terminal domain, is specifically expressed in neurons; the short form is detected in both glial and nonneuronal cells. The related proteins Intersectin-2 and the murine homolog Ese2 also contain the characteristic N-terminal EH domains, the central coiled-coil domain and five C-terminal SH3 domains and are likely involved the endocytic scaffolding complexes.

Intersectin 2抗体Also known as:

Intersectin-2; ITSN2; ITSN2_HUMAN; KIAA1256; PRO2015; SH3 domain-containing protein 1B; SH3D1B; SH3P18; SH3P18-like WASP-associated protein; SWA; SWAP.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from human Intersec.

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Intersectin 2抗体Predicted Molecular Weight: 193kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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