供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL5871R |
CAS号: |
Quantity size:
0.2ml
Concentration:
1mg/ml激肽释放酶8抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Kallikrein 8 (hK8), also known as neuropsin, brain serine protease 1 (BSP1), tumor associated differentially expressed gene 14 (TADG14), PRSS19, HNP and ovasin, is a trypsin like serine protease. Originally described from mouse brain, KLK8 was implicated in neural plasticity and learning. Kallikrein 8 is thought to be involved in neurite outgrowth and fasciculation during nervous system development. Kallikrein 8 is induced in neurite injury, and Kallikrein 8 has been shown to be elevated in the hippocampus on Alzheimer’s patients’ brains. Animal models of autoimmune encephalomyelitis (EAE) 激肽释放酶8抗体show elevated Kallikrein 8 production. Kallikrein 8 null mice have aberrant synapses in their hippocampus, compared to wild type mice, and are predisposed to seizures. Kallikrein 8 is thought to regulate the early phase of long-term potentiation (LTP), possibly by cleaving fibronectin and other substrates. Kallikrein 8 is also found in the uterus, where it is hormonally regulated. Cervical cancer cell lines express high levels of Kallikrein 8,激肽释放酶8抗体 and it may be useful as a tumor marker. Kallikrein 8 is not limited to the brain and uterus, as many tissues and cell lines make the protein. Endogenous inhibitors include serine protease inhibitor 3 and protein C inhibitor, although Kallikrein 8 can be found complexed to a number of different protease inhibitors.
Also known as:
Kallikrein-8; Ovasin; Serine protease TADG 14; Tumor associated differentially expressed gene 14 protein; Brain serine protease 1; BSP1; hK8; HNP; HPN; Kallikrein 8 (neuropsin/ovasin); Kallikrein related peptidase 8; Kallikrein8; KLK 8; KLK8; KLK-8; KLK8 protein type 1; KLK8 protein type 2; Neuropsin; neuropsin type 1; Neuropsin type 1, included; Neuropsin type 2; Neuropsin type 2, included; Neuropsin, mouse, homolog of;激肽释放酶8抗体 NP; NRPN; Protease serine 19; PRSS 19; PRSS19; Serine protease 19; Serine protease kallikrein; Serine protease kallikrein/ovasin/neuropsin; Serine protease TADG14; TADG 14; TA
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig, .
●
Immunogen: KLH conjugated synthetic peptide derived from human KLK8.
●
激肽释放酶8抗体Predicted Molecular Weight: 25kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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kl310Mu01弹性蛋白酶4(ELA4)多克隆抗体Polyclonal Antibody to Elastase 4 (ELA4)
kl311Mu01阿黑皮素原(POMC)多克隆抗体Polyclonal Antibody to Proopiomelanocortin (POMC)
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kl313Hu01整合素α1(ITGα1)多克隆抗体Polyclonal Antibody to Integrin Alpha 1 (ITGa1)
kl313Mu01整合素α1(ITGα1)多克隆抗体Polyclonal Antibody to Integrin Alpha 1 (ITGa1)
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kl317Hu01穿孔素1(PRF1)多克隆抗体Polyclonal Antibody to Perforin 1 (PRF1)
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kl319Ra01微管关联蛋白4(MAP4)多克隆抗体Polyclonal Antibody to Microtubule Associated Protein 4 (MAP4)
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