磷酸化单丝氨酸蛋白激酶2抗体

Quantity size:

0.1ml

Concentration:

1mg/ml磷酸化单丝氨酸蛋白激酶2抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a磷酸化单丝氨酸蛋白激酶2抗体 small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

磷酸化单丝氨酸蛋白激酶2抗体Also known as:

LIM kinase 2 (phospho S291 + S293); p-LIM kinase 2 (phospho S291 + S293); LIM domain kinase 2; LIMK 2; LIMK-2; LIMK2; LIMK2_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,磷酸化单丝氨酸蛋白激酶2抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human LIM Kinase 1 around the phosphorylation site of（Ser291 + Ser293）.

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Predicted Molecular Weight: 72kDa.

磷酸化单丝氨酸蛋白激酶2抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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