细胞生长调节核仁蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 细胞生长调节核仁蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

LYAR is a 379 amino acid nucleolar protein containing two C2HC-type zinc fingers. Expressed at high levels in immature spermatocytes, early embryos and in fetal liver and thymus with low expression in kidney and spleen, LYAR may function as a novel nucleolar oncoprotein to regulate cell growth. It is suggested that LYAR participates in regulating the细胞生长调节核仁蛋白抗体 stability of C23, a protein that is critical for maintaining the self-renewal and differentiation of embryonic stem cells (ESCs). C23 is a eukaryotic nucleolar phosphoprotein that influences synthesis and maturation of ribosomes. LYAR forms a complex with C23, thereby preventing self-cleavage and maintaining steady levels of C23 in undifferentiated ESCs. Downregulation of LYAR decreases C23 stability in ESCs, which in turn negatively affects growth and increases the rate of apoptosis of these cells.

细胞生长调节核仁蛋白抗体Also known as:

Cell growth regulating nucleolar protein; Cell growth-regulating nucleolar protein; Likely ortholog of mouse Ly1; reactive clone; Ly1; reactive; Ly1; reactive homolog (mouse); Ly1; reactive homolog; LYAR; LYAR_HUMAN; ZC2HC2; ZLYAR.

Specificity:

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Rabbit Polyclonal IgG,细胞生长调节核仁蛋白抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from human LYAR.

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Predicted Molecular Weight: 44kDa.

细胞生长调节核仁蛋白抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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