髓鞘少树突胶质细胞糖蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 髓鞘少树突胶质细胞糖蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The髓鞘少树突胶质细胞糖蛋白抗体 amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive髓鞘少树突胶质细胞糖蛋白抗体function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ.

Also known as:

myelin oligo-dendrocyte glycoprotein-MOG; MGC26137; MOG alpha 6; MOG; MOGIG2; Myelin oligodendrocyte glycoprotein; MOG_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,髓鞘少树突胶质细胞糖蛋白抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Pig, Guinea Pig, .

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Immunogen: KLH conjugated synthetic peptide derived from Guinea pig MOG(35-55).

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Predicted Molecular Weight: 24kDa.

髓鞘少树突胶质细胞糖蛋白抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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