基质金属蛋白酶-12抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 基质金属蛋白酶-12抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis, metastasis, and atherosclerosis. Most MMP's are secreted as inactive proproteins which are基质金属蛋白酶-12抗体 activated when cleaved by extracellular proteinases.
MMP12 was first described in murine macrophages, later in human macrophages, and more recently in other cell types. Also known as metalloelastase, MMP12 is able to degrade elastin, entactin, laminin 1, fibronectin, type IV collagen as well as insulin B-chain and casein. MMP12 is often confused with the Serine proteinase, Leukocyte elastase (EC 3.4.21.37) because of similar nomenclature. MMP12 is structurally similar to 基质金属蛋白酶-12抗体the classical MMPs (MMP1, MMP3); it contains a propeptide with autoinhibitory cysteine switch site, a well-conserved zinc site, hinge region and hemopexin domain. MMP12 lacks a transmembrane domain and furin cleavage site. The zymogen for MMP-12 is about 54 kD, and is quickly activated to the 45 kD form; and this breaks down to cascade of active forms, ending with the common 22 kD form. Stimulated macrophages produce MMP12; it has also been found in osteosarcoma cells, synovial fibroblasts and lung fibroblasts.

基质金属蛋白酶-12抗体Also known as:

matrix metalloproteinase 12; MMP12; EC 3.4.24.65; HME; Macrophage elastase; Macrophage metaloelastase; Matrix metalloprotease 12; ME; MGC138506; MME; MMP 12; MMP12_HUMAN; MMP 12; MMP-12; MMP12.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, .

●

Immunogen: KLH conjugated synthetic peptide derived from human MMP12.

●

基质金属蛋白酶-12抗体Predicted Molecular Weight: 40/49kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl697Hu01α1-抗胰蛋白酶(α1AT)多克隆抗体Polyclonal Antibody to Alpha-1-Antitrypsin (a1AT)

kl697Mu01α1-抗胰蛋白酶(α1AT)多克隆抗体Polyclonal Antibody to Alpha-1-Antitrypsin (a1AT)

kl697Ra01α1-抗胰蛋白酶(α1AT)多克隆抗体Polyclonal Antibody to Alpha-1-Antitrypsin (a1AT)

kl817Hu01结合珠蛋白(Hpt)多克隆抗体Polyclonal Antibody to Haptoglobin (Hpt)

kl817Mu01结合珠蛋白(Hpt)多克隆抗体Polyclonal Antibody to Haptoglobin (Hpt)

kl817Ra01结合珠蛋白(Hpt)多克隆抗体Polyclonal Antibody to Haptoglobin (Hpt)

kl817Gu01结合珠蛋白(Hpt)多克隆抗体Polyclonal Antibody to Haptoglobin (Hpt)

kl817Rb53结合珠蛋白(Hpt)多克隆抗体Polyclonal Antibody to Haptoglobin (Hpt)

kl236Hu01纤溶酶原(Plg)多克隆抗体Polyclonal Antibody to Plasminogen (Plg)

kl236Mu01纤溶酶原(Plg)多克隆抗体Polyclonal Antibody to Plasminogen (Plg)

kl236Ra01纤溶酶原(Plg)多克隆抗体Polyclonal Antibody to Plasminogen (Plg)

kl017Hu01α2-巨球蛋白(α2M)多克隆抗体Polyclonal Antibody to Alpha-2-Macroglobulin (a2M)

kl017Mu01α2-巨球蛋白(α2M)多克隆抗体Polyclonal Antibody to Alpha-2-Macroglobulin (a2M)

kl017Ra01α2-巨球蛋白(α2M)多克隆抗体Polyclonal Antibody to Alpha-2-Macroglobulin (a2M)

kl780Hu01乳铁传递蛋白(LTF)多克隆抗体Polyclonal Antibody to Lactoferrin (LTF)

kl780Mu01乳铁传递蛋白(LTF)多克隆抗体Polyclonal Antibody to Lactoferrin (LTF)

kl780Ra01乳铁传递蛋白(LTF)多克隆抗体Polyclonal Antibody to Lactoferrin (LTF)

kl667Hu01葡萄糖激酶(GCK)多克隆抗体Polyclonal Antibody to Glucokinase (GCK)

kl667Mu01葡萄糖激酶(GCK)多克隆抗体Polyclonal Antibody to Glucokinase (GCK)

kl667Ra01葡萄糖激酶(GCK)多克隆抗体Polyclonal Antibody to Glucokinase (GCK)

kl120Hu01精氨酸酶(ARG)多克隆抗体Polyclonal Antibody to Arginase (ARG)

kl120Mu01精氨酸酶(ARG)多克隆抗体Polyclonal Antibody to Arginase (ARG)

kl120Ra01精氨酸酶(ARG)多克隆抗体Polyclonal Antibody to Arginase (ARG)

kl846Hu01催乳素(PRL)多克隆抗体Polyclonal Antibody to Prolactin (PRL)

kl846Mu01催乳素(PRL)多克隆抗体Polyclonal Antibody to Prolactin (PRL)