磷酸化丝裂原活化蛋白激酶激酶5抗体

uantity size:

0.1ml

Concentration:

1mg/ml 磷酸化丝裂原活化蛋白激酶激酶5抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

MEK5 is a dual specificity protein kinase belonging to thr Ser/Thr protein kinase family, (MAP kinase kinase family). It is activated by phosphorylation on Ser/Thr by MAP kinase kinases and interacts specifically with ERK5, and not with another MAP kinase like P38. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself磷酸化丝裂原活化蛋白激酶激酶5抗体 can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). It is not phosphorylated by RAFA, RAFB or RAFC and it may interact with GTPases such as CDC42. The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. MEK5 is expressed in many adult tissues and is most abundant in heart and skeletal muscle.

磷酸化丝裂原活化蛋白激酶激酶5抗体Also known as:

MAP2K5 (phospho S142); Dual specificity mitogen activated protein kinase kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAP2K5; MAPK/ERK kinase 5; MAPKK5; PRKMK5; EC 2.7.12.2; MP2K5_HUMAN; Dual specificity mitogen-activated protein kinase kinase 5; MAPKK 5; MAPK/ERK kinase 5; MEK 5.

Specificity:

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Rabbit Polyclonal IgG,磷酸化丝裂原活化蛋白激酶激酶5抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human MEK5 around the phosphorylation site of Ser142.

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Predicted Molecular Weight: 49kDa.

磷酸化丝裂原活化蛋白激酶激酶5抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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