供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL-5842R |
CAS号: |
Quantity size:
0.2ml
Concentration:
1mg/ml IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposingIGFBP2结合蛋白/迁移和侵润抑制蛋白抗体 effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway.
IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体Also known as:
FLJ12438; FLJ38609; IGFBP 2 binding protein; IGFBP2 binding protein; IIP45; Invasion inhibitory protein 45; Migration and invasion inhibitory protein; RP5 1077B9.4.
Specificity:
●
Rabbit Polyclonal IgG,IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体 affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, .
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Immunogen: KLH conjugated synthetic peptide derived from human MIIP.
●
Predicted Molecular Weight: 43kDa.
IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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