IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

MIIP has 3 SEG (segments of low compositional complexity) domains, an RGD motif, and several potential phosphorylation sites. The C-terminal region of IGFBP2 interacts with a central 44-amino acid sequence of MIIP. MIIP inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. It exhibits opposingIGFBP2结合蛋白/迁移和侵润抑制蛋白抗体 effects to IGFBP2 on cell invasion. There are 2 named isoforms due to alternative splicing. Isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level. Isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression. On the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells. Isoform 2 is degraded by the ubiquitin-proteasome pathway.

IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体Also known as:

FLJ12438; FLJ38609; IGFBP 2 binding protein; IGFBP2 binding protein; IIP45; Invasion inhibitory protein 45; Migration and invasion inhibitory protein; RP5 1077B9.4.

Specificity:

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Rabbit Polyclonal IgG,IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, .

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Immunogen: KLH conjugated synthetic peptide derived from human MIIP.

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Predicted Molecular Weight: 43kDa.

IGFBP2结合蛋白/迁移和侵润抑制蛋白抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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