线粒体rRNA甲基转移酶1抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 线粒体rRNA甲基转移酶1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

MRM1 is a 353 amino acid protein that localizes to the mitochondrion and belongs to the RNA methyltransferase trmH family. Expressed as two alternatively spliced isoforms, MRM1 specifically methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S). The gene encoding MRM1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 线粒体rRNA甲基转移酶1抗体genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic 线粒体rRNA甲基转移酶1抗体determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.

线粒体rRNA甲基转移酶1抗体Also known as:

A530065E19Rik; ENSMUSG00000054212; FLJ22578; Mitochondrial large ribosomal RNA ribose methylase; Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae); MRM1; MRM1_HUMAN; OTTMUSP00000008034; RGD1566232; RP23-293L24.6; rRNA methyltransferase 1, mitochondrial.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human MRM1.

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Predicted Molecular 线粒体rRNA甲基转移酶1抗体Weight: 36kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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