肌动蛋白交联蛋白家族7抗体

Quantity size:

0.2ml

Concentration:

1mg/ml  肌动蛋白交联蛋白家族7抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Microtubule-actin crosslinking factor 1 (MACF1/ACF7) belongs to spectraplakin family of proteins which also includes mammalian Bpag1/dystonin, Drosophila Short Stop (Shot) and Caenorhabditis elegans Vab-10. These are large actin-microtubule linker molecules that are essential for various biological processes such as neuronal degeneration, wound healing, gastrulation. MACF1, located on mouse chromosome 4D2.2, was found to 肌动蛋白交联蛋白家族7抗体play an important role during neurogenesis- it was shown that MACF1 regulates the organization of neuronal microtubules which is essential for axon extension. Furthermore, MACF1 is required in controlling肌动蛋白交联蛋白家族7抗体 focal adhesion assembly and dynamics. MACF1 behaves as an actin-regulated ATPase and it has the ability to target microtubules that track along F-actin to focal adhesions. MACF1 was also implicated in regulating filopodia formation.

Also known as:

ABP620; Acf7; Aclp7; Actin cross linking family 7; MACF; Microtubule actin crosslinking factor 1; mKIAA0465; R74989; rabeculin alpha.

Specificity:

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Rabbit Polyclonal IgG,肌动蛋白交联蛋白家族7抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Cow, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human MACF1/ACF7.

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肌动蛋白交联蛋白家族7抗体Predicted Molecular Weight: 839kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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