磷酸化DNA损伤关卡蛋白1抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化DNA损伤关卡蛋白1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase  磷酸化DNA损伤关卡蛋白1抗体cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]

 磷酸化DNA损伤关卡蛋白1抗体Also known as:

MDC1 (phospho S964); p-MDC1 (phospho S964); DKFZp781A0122; Homologue to Drosophila photoreceptor protein calphotin; KIAA0170; KIAA0170; MDC 1; Mdc1; MDC1_HUMAN; Mediation of DNA damage checkpoint 1; Mediator of DNA damage checkpoint 1; Mediator of DNA Damage Checkpoint Protein 1; Mediator of DNA Damage Checkpoint Protein 1; NFBD 1; NFBD1; NFBD1; Nuclear factor with BRCT domains 1; Nuclear Factor with BRCT Domains Protein 1; Nuclear  磷酸化DNA损伤关卡蛋白1抗体Factor with BRCT Domains Protein 1.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human MDC1 around the phosphorylation site of Ser964.

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Predicted Molecular Weight: 227kDa.

 磷酸化DNA损伤关卡蛋白1抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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