去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Catecholamine, a term used for the hormone adrenaline and its sequentially hydroxylated form noradrenaline, is involved in fight or flight responses. Noradrenaline is released from the post ganglionic sympathetic nerve endings and exerts its effects locally in the immediate vicinity of its release. In the CNS, noradrenaline is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors, and control of the endocrine and autonomic nervous systems. Peripherally, noradrenaline is present in sympathetic nerve endings and has full control of the sympathetic nervous system. Noradrenaline released from pre-synaptic nerve terminals 去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体is reabsorbed (70-90%) by noradrenaline transporters and its biological effects are terminated. The noradrenaline transport via noradrenaline transporters is an active, Na+/Cl- dependent transport process mediated by noradrenaline transporters. Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, are targets for multiple antidepressants and psychostimulants, and are deficient in affective and autonomic disorders. In rat brain, noradrenaline transporter is expressed in noradrenergic neuronal somata, axons and dendrites, and hippocampus and cortex, but is absent from epinephrine- and dopamine-containing neurons. At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake and concentrations in 去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体cerebrospinal fluid in humans. The association between these genetic variations in noradrenaline transporters and several psychiatric and cardiovascular disorders is just emerging. Recently, a single amino acid mutation (hNET-A457P) showed deficiency in noradrenaline transport in an orthostatic intolerance patient. Noradrenaline transporter protein consists of 617 amino acids and has 12 trans-membrane domains, a characteristic feature of many membrane associated solute transporters.

去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体Also known as:

NAT1; NET; NET; NET1; Norepinephrine transporter; SLC6A2; SLC6A5; SLC6A5; Sodium dependent noradrenaline transporter; Solute carrier family 6 (neurotransmitter transporter norepinephrine) member 5; Solute carrier family 6 member 2; Solute carrier family 6 member 2.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, .

●

Immunogen: KLH conjugated synthetic peptide derived from human NET1.

●

去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体抗体Predicted Molecular Weight: 65kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl569Ra01酶原颗粒膜糖蛋白(GP2)多克隆抗体Polyclonal Antibody to Glycoprotein 2, Zymogen Granule Membrane (GP2)

kl570Hu01α1-B-糖蛋白(α1BG)多克隆抗体Polyclonal Antibody to Alpha-1-B-Glycoprotein (a1BG)

kl571Hu01卷曲同源物1(FZD1)多克隆抗体Polyclonal Antibody to Frizzled Homolog 1 (FZD1)

kl576Hu01卷曲同源物6(FZD6)多克隆抗体Polyclonal Antibody to Frizzled Homolog 6 (FZD6)

kl593Hu01泛素关联蛋白2(UBAP2)多克隆抗体Polyclonal Antibody to Ubiquitin Associated Protein 2 (UBAP2)

kl594Hu01泛素结合酶E2C(UBE2C)多克隆抗体Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C)

kl624Mu01周期素依赖性激酶抑制因子1A(CDKN1A)多克隆抗体Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 1A (CDKN1A)

kl624Ra01周期素依赖性激酶抑制因子1A(CDKN1A)多克隆抗体Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 1A (CDKN1A)

kl645Hu01FK506结合蛋白5(FKBP5)多克隆抗体Polyclonal Antibody to FK506 Binding Protein 5 (FKBP5)

kl651Hu01微小染色体维持缺陷蛋白5(MCM5)多克隆抗体Polyclonal Antibody to Minichromosome Maintenance Deficient 5 (MCM5)

kl671Hu01SHC-转化蛋白1(SHC1)多克隆抗体Polyclonal Antibody to SHC-Transforming Protein 1 (SHC1)

kl673Hu01羟甲基胆素合酶(HMBS)多克隆抗体Polyclonal Antibody to Hydroxymethylbilane Synthase (HMBS)

kl674Hu01再生胰岛衍生蛋白1β(REG1β)多克隆抗体Polyclonal Antibody to Regenerating Islet Derived Protein 1 Beta (REG1b)

kl675Hu01再生胰岛衍生蛋白3α(REG3α)多克隆抗体Polyclonal Antibody to Regenerating Islet Derived Protein 3 Alpha (REG3a)

kl675Ra01再生胰岛衍生蛋白3α(REG3α)多克隆抗体Polyclonal Antibody to Regenerating Islet Derived Protein 3 Alpha (REG3a)

kl676Hu01再生胰岛衍生蛋白3γ(REG3γ)多克隆抗体Polyclonal Antibody to Regenerating Islet Derived Protein 3 Gamma (REG3g)

kl676Mu01再生胰岛衍生蛋白3γ(REG3γ)多克隆抗体Polyclonal Antibody to Regenerating Islet Derived Protein 3 Gamma (REG3g)

kl698Hu01鞘氨醇激酶1(SPHK1)多克隆抗体Polyclonal Antibody to Sphingosine Kinase 1 (SPHK1)

kl707Mu01微管蛋白β1(TUBβ1)多克隆抗体Polyclonal Antibody to Tubulin Beta 1 (TUBb1)

kl711Hu01微管蛋白β3(TUBβ3)多克隆抗体Polyclonal Antibody to Tubulin Beta 3 (TUBb3)

kl748Hu01亲核素α2(KPNα2)多克隆抗体Polyclonal Antibody to Karyopherin Alpha 2 (KPNa2)

kl762Hu01干扰素γ诱导蛋白30(IFI30)多克隆抗体Polyclonal Antibody to Interferon Gamma Inducible Protein 30 (IFI30)

kl765Hu01白介素23受体(IL23R)多克隆抗体Polyclonal Antibody to Interleukin 23 Receptor (IL23R)