γ-分泌酶组件蛋白NCLN抗体

Quantity size:

0.2ml

Concentration:

1mg/ml  γ-分泌酶组件蛋白NCLN抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate γ-分泌酶组件蛋白NCLN抗体decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor forγ-分泌酶组件蛋白NCLN抗体 melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype.

γ-分泌酶组件蛋白NCLN抗体Also known as:

NCLN; NCLN_HUMAN; NET59; Nicalin; Nicalin homolog (zebrafish); Nicastrin like protein; Nicastrin-like protein.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from human Nicalin (401-500aa).

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Predicted Molecular Weight: 59kDa.

Storage:

γ-分泌酶组件蛋白NCLN抗体Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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