神经组织特异性F肌动蛋白结合蛋白2抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 神经组织特异性F肌动蛋白结合蛋白2抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Neurabin-II, also called spinophilin, interacts with actin and PP-1 in dendritic spines of the central nervous system (1,2). The gene encoding human neurabin-II maps to chromosome 17q21-q22 (2). The structural characteristics of neurabin-II include one F-actin binding domain at the N-terminal region, a predicted coiled-coil struture at the C-terminal, one PDZ domain at the middle region, and a domain known to interact with transmembrane proteins (1). Neurabin-II bundles actin fliaments in vitro (1). In vivo, 神经组织特异性F肌动蛋白结合蛋白2抗体 spinophilin localizes to the cortical sites of actin filaments and to the sites of active membrane remodelling (4). Neurabin-II also forms a complex with the catalytic subunit of PP1 and modulates PP1 enzymatic activity in vitro (2). Neurabin-II localizes to the head of dendritic spines (2) and aids in the ability of PP-1 to regulate the activity of 神经组织特异性F肌动蛋白结合蛋白2抗体 a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-asparate (NMDA) receptors (3). In this manner, neurabin-II modulates both glutamatergic synaptic transmission and dendritic morphology (3). Synergistic interactions between spinophilin and human tumor supressor ARF suggest a role for neurabin-II in cell growth (5).

神经组织特异性F肌动蛋白结合蛋白2抗体 Also known as:

FLJ30345; NEB2_HUMAN; Neurabin II; Neurabin-2; Neurabin-II; Neurabin2; NeurabinII; Neurabin II; Neural tissue specific F actin binding protein II; p130; PP1bp134; PPP1R6; PPP1R9; PPP1R9B; Protein phosphatase 1 regulatory subunit 9B; SPINO; Spinophilin.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Sheep, .

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Immunogen: KLH conjugated synthetic peptide derived from human Spinophilin/Neurabin 2.

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神经组织特异性F肌动蛋白结合蛋白2抗体 Predicted Molecular Weight: 89kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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kl705Bo01粘蛋白2(MUC2)多克隆抗体Polyclonal Antibody to Mucin 2 (MUC2)

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kl413Ra01粘蛋白1(MUC1)多克隆抗体Polyclonal Antibody to Mucin 1 (MUC1)

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kl817Ra01结合珠蛋白(Hpt)多克隆抗体Polyclonal Antibody to Haptoglobin (Hpt)

kl817Gu01结合珠蛋白(Hpt)多克隆抗体Polyclonal Antibody to Haptoglobin (Hpt)

kl817Rb53结合珠蛋白(Hpt)多克隆抗体Polyclonal Antibody to Haptoglobin (Hpt)

kl236Hu01纤溶酶原(Plg)多克隆抗体Polyclonal Antibody to Plasminogen (Plg)

kl236Mu01纤溶酶原(Plg)多克隆抗体Polyclonal Antibody to Plasminogen (Plg)

kl236Ra01纤溶酶原(Plg)多克隆抗体Polyclonal Antibody to Plasminogen (Plg)

kl017Hu01α2-巨球蛋白(α2M)多克隆抗体Polyclonal Antibody to Alpha-2-Macroglobulin (a2M)

kl017Mu01α2-巨球蛋白(α2M)多克隆抗体Polyclonal Antibody to Alpha-2-Macroglobulin (a2M)

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