胰岛素促进因子/胰十二指肠同源异型盒蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml胰岛素促进因子/胰十二指肠同源异型盒蛋白抗体   Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the胰岛素促进因子/胰十二指肠同源异型盒蛋白抗体 hormone-producing phenotype of the beta-cell. Insulin promoter factor 1 is an islet-specific protein that activates transcription of the insulin andsomatostatin genes. It is a key regulator of islet peptide hormone expressionn and also plays an essential role in pancreatic development. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus. Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. & Contains 1 homeobox DNA-binding domain. Subcellular Location: Nucleus. Tissue Specificity: Duodenum and pancreas.

胰岛素促进因子/胰十二指肠同源异型盒蛋白抗体Also known as:

Glucose sensitive factor; Glucose-sensitive factor; GSF; IDX 1; IDX-1; IDX1; Insulin promoter factor 1; insulin promoter factor 1 homeodomain transcription factor; insulin upstream factor 1; IPF 1; IPF-1; IPF1; Islet/duodenum homeobox 1; Islet/duodenum homeobox-1; IUF 1; IUF-1; IUF1; MODY4; Pancreas/duodenum homeobox 1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox P; PDX 1; PDX-1; PDX1; PDX1_HUMAN;胰岛素促进因子/胰十二指肠同源异型盒蛋白抗体 Somatostatin transactivating factor 1; Somatostatin-transactivating factor 1; STF 1; STF-1; STF1.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Pig, .

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Immunogen: KLH conjugated synthetic peptide derived from human PDX1.

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胰岛素促进因子/胰十二指肠同源异型盒蛋白抗体Predicted Molecular Weight: 30kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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