DNA修复蛋白NBS1抗体

Quantity size:

0.2ml

Concentration:

1mg/ml DNA修复蛋白NBS1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them  DNA修复蛋白NBS1抗体in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability.

 DNA修复蛋白NBS1抗体Also known as:

p95 NBS1; Nijmegen breakage syndrome 1; Nijmegen breakage syndrome 1 (nibrin); AT V1; AT V2; ATV; Cell cycle regulatory protein p95; FLJ10155; MGC87362; MGC93174; NBN; NBS 1; NBS; NBS1; Nibrin; Nijmegen breakage syndrome; Nijmegen breakage syndrome protein 1; p95; NBN_HUMAN; Nibrin; Nijmegen breakage syndrome protein 1.

Specificity:

●

Rabbit Polyclonal IgG, DNA修复蛋白NBS1抗体 affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, .

●

Immunogen: KLH conjugated synthetic peptide derived from human NBS1.

●

Predicted Molecular Weight: 85kDa.

 DNA修复蛋白NBS1抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl406Ra01脂多糖结合蛋白(LBP)多克隆抗体Polyclonal Antibody to Lipopolysaccharide Binding Protein (LBP)

kl416Hu01葡萄糖苷酸酶β(GUSβ)多克隆抗体Polyclonal Antibody to Glucuronidase Beta (GUSb)

kl416Mu01葡萄糖苷酸酶β(GUSβ)多克隆抗体Polyclonal Antibody to Glucuronidase Beta (GUSb)

kl416Ra01葡萄糖苷酸酶β(GUSβ)多克隆抗体Polyclonal Antibody to Glucuronidase Beta (GUSb)

kl426Hu01CD99分子(CD99)多克隆抗体Polyclonal Antibody to Cluster Of Differentiation 99 (CD99)

kl429Hu01多巴胺β羟化酶(DβH)多克隆抗体Polyclonal Antibody to Dokline Beta Hydroxylase (DbH)

kl430Hu01信号素4D(SEMA4D)多克隆抗体Polyclonal Antibody to Semaphorin 4D (SEMA4D)

kl434Hu01蛋白酶3(PR3)多克隆抗体Polyclonal Antibody to Proteinase 3 (PR3)

kl434Mu01蛋白酶3(PR3)多克隆抗体Polyclonal Antibody to Proteinase 3 (PR3)

kl434Ra01蛋白酶3(PR3)多克隆抗体Polyclonal Antibody to Proteinase 3 (PR3)

kl438Hu01酪氨酸羟化酶(TH)多克隆抗体Polyclonal Antibody to Tyrosine Hydroxylase (TH)

kl438Mu01酪氨酸羟化酶(TH)多克隆抗体Polyclonal Antibody to Tyrosine Hydroxylase (TH)

kl438Ra01酪氨酸羟化酶(TH)多克隆抗体Polyclonal Antibody to Tyrosine Hydroxylase (TH)

kl440Hu01整合素β4(ITGβ4)多克隆抗体Polyclonal Antibody to Integrin Beta 4 (ITGb4)

kl443Hu01胎盘蛋白13(PP13)多克隆抗体Polyclonal Antibody to Placental Protein 13 (PP13)

kl447Ra01乙酰胆碱酯酶(AchE)多克隆抗体Polyclonal Antibody to Acetylcholinesterase (AchE)

kl448Hu01信号素7A(SEMA7A)多克隆抗体Polyclonal Antibody to Semaphorin 7A (SEMA7A)

kl448Mu01信号素7A(SEMA7A)多克隆抗体Polyclonal Antibody to Semaphorin 7A (SEMA7A)

kl449Hu01非神经元性烯醇化酶(NNE)多克隆抗体Polyclonal Antibody to Enolase, Non Neuronal (NNE)

kl449Ra01非神经元性烯醇化酶(NNE)多克隆抗体Polyclonal Antibody to Enolase, Non Neuronal (NNE)

kl451Mu01早期生长应答因子2(EGR2)多克隆抗体Polyclonal Antibody to Early Growth Response Protein 2 (EGR2)

kl453Ra01胰脂肪酶(PL)多克隆抗体Polyclonal Antibody to Likle, klcreatic (PL)

kl461Hu01天青杀素1(AZU1)多克隆抗体Polyclonal Antibody to Azurocidin 1 (AZU1)