磷酸化蛋白激酶C β1/β2(Thr500)抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化蛋白激酶C β1/β2(Thr500)抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Protein kinase C (PKC) is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. 
Protein Kinase C beta (PKC beta) is an 80 kDa member of the conventional group (cPKCs: sensitive to diacylglycerol, phosphotidylserine and phorbol esters) of the PKC family of serine/threonine kinases磷酸化蛋白激酶C β1/β2(Thr500)抗体 that are involved in a wide range of physiological processes including mitogenesis, cell survival, transcriptional regulation and tumor promotion. PKC beta has been implicated in diabetes and carcinogenesis. PKC beta isoforms 1 & 2 are phosphorylated on three sites, threonine 500 in the activation loop, beta 1 threonine 642 (beta 2 641) in the turn loop and beta 1 serine 661 (beta 2 660) in the hydrophobic loop. Phosphorylation of PKC beta 1 & 2 on threonine 500 by PDK1 is a prerequisite for its autophosphoylation and catalytic competence.

磷酸化蛋白激酶C β1/β2(Thr500)抗体Also known as:

PKC beta 1 + PKC beta 2 (phospho T500); PKC beta 1 + PKC beta 2 (phospho Thr500); MGC41878; PKC B; PKC beta; PKCB; PKCB1; PKCB2; PKCbeta; PRKCB 1; PRKCB 2; PRKCB; PRKCB I; PRKCB II; PRKCB1; PRKCB2; Protein kinase C beta 1; Protein kinase C beta 1; Protein kinase C beta 2; Protein kinase C beta; Protein kinase C beta type; KPCB_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,磷酸化蛋白激酶C β1/β2(Thr500)抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human PKC beta 1 around the phosphorylation site of (Thr500).

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磷酸化蛋白激酶C β1/β2(Thr500)抗体Predicted Molecular Weight: 81kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user

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