磷酸化蛋白激酶AKT底物1抗体

Quantity size:

0.1ml

Concentration:

1mg/ml  磷酸化蛋白激酶AKT底物1抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Proline Rich Akt Substrate (PRAS40) is a 40 kDa substrate of Akt. Akt and PRAS40 can be found in the phosphoinositide 3 kinase (PI3K) pathway, which plays a role in glucose uptake, cell growth, and apoptosis inhibition. PRAS40 is a 14-3-3 binding protein that reacts with insulin,磷酸化蛋白激酶AKT底物1抗体 but whose precise function is not yet known. It may bind SH3 and WW domain containing proteins resulting in a change of function. Activated Akt phosphorylates PRAS40 on threonine 246. Mutation of PRAS40 threonine 246 has been shown to be apoptotic.

磷酸化蛋白激酶AKT底物1抗体Also known as:

PRAS40 (Phospho Thr246); PRAS40 (Phospho T246); AKT1 substrate 1 (proline rich); AKT1 substrate 1; AKT1-S1; AKT1S-1; AKT1S1; Lobe; PRAS 40; PRAS-40; PRAS40; Proline rich akt substrate; 40 kDa proline rich AKT substrate; AKTS1_HUMAN.

Specificity:

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Rabbit Polyclonal I磷酸化蛋白激酶AKT底物1抗体gG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Cow, Horse, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human PRAS40 around the phosphorylation site of Thr246.

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磷酸化蛋白激酶AKT底物1抗体Predicted Molecular Weight: 28kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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