磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Phosphofructokinases (PFKs) are regulatory glycolytic enzymes that catalyze the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. Mammalian PFK is a tetramer made up of diverse combinations of three isoenzymes: muscle (PFK-1), liver (PFKL) and platelet (PFKP). PFKL (phosphofructokinase, liver), also referred to磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体 as PFK-B (Phosphofructo-1-kinase isozyme B), phosphofructokinase 1 or phosphohexokinase, predominates in organs with active gluconeogenesis, such as liver and kidney. Overexpression of PFKL in transgenic mice results in a diminished glucose-induced insulin response, which suggests that PFKL may play a role in glucose-induced insulin secretion. PFKL is expressed at high levels in Down's syndrome (DS) patients, suggesting a possible role for PFKL in the pathogenesis of DS.

磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体Also known as:

PFKL (phospho S775); PFKL (phospho Ser775); p-PFKL (Ser775); ATP-dependent 6-phosphofructokinase, liver type; ATP-PFK; PFK-L; 6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; PFK-B; Phosphohexokinase; Phosphohexokinase; PFKAL_HUMAN。

Specificity:

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Rabbit Polyclonal IgG磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human PFKL around the phosphorylation site of Ser775.

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磷酸化肝型6磷酸果糖激酶/磷酸果糖激酶1抗体Predicted Molecular Weight: 86kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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