磷酸化磷脂酰肌醇激酶催化亚单位A抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化磷脂酰肌醇激酶催化亚单位A抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K which uses ATP to phosphorylate PtdIns磷酸化磷脂酰肌醇激酶催化亚单位A抗体, PtdIns4P and PtdInsP2. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach.

磷酸化磷脂酰肌醇激酶催化亚单位A抗体Also known as:

PIK3CA(phospho Y317); caPI3K; MGC142161; MGC142163; p110 alpha ; p110 alpha; Phosphatidylinositol 3 kinase catalytic alpha polypeptide; Phosphatidylinositol 3 kinase catalytic 110 KD alpha; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform; Phosphoinositide 3 kinase catalytic alpha polypeptide; PI3 kinase p110 磷酸化磷脂酰肌醇激酶催化亚单位A抗体subunit alpha; PI3K; PI3KC A; PIK3C A; PIK3CA; PK3CA; PtdIns 3 kinase p110;PI3-kinase P110α.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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磷酸化磷脂酰肌醇激酶催化亚单位A抗体Immunogen: KLH conjugated Synthesised phosphopeptide derived from human PI3KCA around the phosphorylation site of Tyr317.

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Predicted Molecular Weight: 117kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user

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