磷酸化蛋白磷酸酶2C亚型α抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化蛋白磷酸酶2C亚型α抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also 磷酸化蛋白磷酸酶2C亚型α抗体 dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

磷酸化蛋白磷酸酶2C亚型α抗体 Also known as:

PPM1A(phospho S375); Mpp alpha; PP2C alpha; PP2C-alpha; PP2CA; PPM 1A; PPM1A; PPM1A_HUMAN; PPPM1A; Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform; Protein phosphatase 1A; Protein phosphatase 1A magnesium dependent alpha; Protein phosphatase 2C alpha; Protein phosphatase 2C alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; Protein phosphatase 2C isoform alpha; IA antibody.

Specificity:

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Rabbit Polyclonal IgG, 磷酸化蛋白磷酸酶2C亚型α抗体 affinity purified by Protein A.

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Reacts with: Human, Dog, Cow, Sheep, Guinea Pig, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human PPM1A around the phosphorylation site of Ser375.

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磷酸化蛋白磷酸酶2C亚型α抗体 Predicted Molecular Weight: 42kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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