肿瘤抑制基因PHLPP抗体

Quantity size:

0.2ml

Concentration:

1mg/ml  肿瘤抑制基因PHLPP抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers肿瘤抑制基因PHLPP抗体 apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.

肿瘤抑制基因PHLPP抗体Also known as:

hSCOP; PH domain and leucine rich repeat protein phosphatase; PH domain leucine rich repeat containing protein phosphatase; PH domain leucine rich repeat protein phosphatase; PH domain leucine-rich repeat protein phosphatase; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase; PH domain-containing family E member 1; PHLP1_HUMAN; PHLPP1; Pleckstrin homology domain containing family E protein 1; Pleckstrin homology domain-containing family E member 1; Pleckstrin homology domain-containing family E 肿瘤抑制基因PHLPP抗体protein 1; PLEKHE 1 protein; SCN circadian oscillatory protein; SCOP; SUPRACHIASMATIC NUCLEUS CIRCADIAN OSCILLATORY PROTEIN; Suprachiasmatic nucleus circadian protein.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, .

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肿瘤抑制基因PHLPP抗体Immunogen: KLH conjugated synthetic peptide derived from human PHLP.

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Predicted Molecular Weight: 34kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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