磷酸化视网膜母细胞瘤样蛋白p107抗体

Quantity size:

0.1ml

Concentration:

1mg/ml  磷酸化视网膜母细胞瘤样蛋白p107抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

p107 is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large 磷酸化视网膜母细胞瘤样蛋白p107抗体T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

磷酸化视网膜母细胞瘤样蛋白p107抗体Also known as:

p107 (phospho T369); p-p107 (phospho T369); RBL1(phospho T369); 107 kDa retinoblastoma-associated protein; Cellular protein 107; Cellular protein p107; CP107; MGC40006; p107; PRB1; RBL1; RBL1_HUMAN; Retinoblastoma like protein 1; retinoblastoma-like 1 (p107); Retinoblastoma-like protein 1.

Specificity:

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Rabbit Polyclonal IgG,磷酸化视网膜母细胞瘤样蛋白p107抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human p107 around the phosphorylation site of Thr369.

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磷酸化视网膜母细胞瘤样蛋白p107抗体Predicted Molecular Weight: 121kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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