多腺苷二磷酸多聚酶3抗体/多聚ADP-核糖聚合酶3

Quantity size:

0.2ml

Concentration:

1mg/ml 多腺苷二磷酸多聚酶3抗体/多聚ADP-核糖聚合酶3  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint.多腺苷二磷酸多聚酶3抗体/多聚ADP-核糖聚合酶3 Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Tissue specificity: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

多腺苷二磷酸多聚酶3抗体/多聚ADP-核糖聚合酶3Also known as:

hPARP3; IRT1; NAD(+) ADP ribosyltransferase 3; pADPRT 3; Poly[ADP ribose] synthetase 3; ADP ribosyltransferase (NAD+; poly (ADP ribose); ADPRT-3; ADPRT3; ADPRTL2; ADPRTL3; hPARP 3; hPARP-3; IRT 1; IRT1; NAD(+) ADP-ribosyltransferase 3; NAD+ ADP ribosyltransferase 3; pADPRT-3; pADPRT3; PARP 3; PARP-3; PARP3; Poly (ADP ribose) polymerase family, member 3; Poly (ADP ribose) synthetase 3; Poly [ADP-ribose] polymerase 3; Poly[ADP-ribose] synthase 3.

Specificity:

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Rabbit Polyclonal IgG,多腺苷二磷酸多聚酶3抗体/多聚ADP-核糖聚合酶3 affinity purified by Protein A.

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Reacts with: Human, Rat, Horse, Rabbit, .

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Immunogen: KLH conjugated synthetic peptide derived from human PARP3.

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多腺苷二磷酸多聚酶3抗体/多聚ADP-核糖聚合酶3Predicted Molecular Weight: 60kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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