磷酸化早幼粒细胞白血病蛋白抗体

Quantity size:

0.1ml

Concentration:

1mg/ml磷酸化早幼粒细胞白血病蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and 磷酸化早幼粒细胞白血病蛋白抗体it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

磷酸化早幼粒细胞白血病蛋白抗体Also known as:

PML Protein (phospho S518); p-PML Protein (phospho S518); Acure promyelocytic leukemia, inducer of; MYL; Pml; PML_HUMAN; PP8675; Probable transcription factor PML; Promyelocytic leukemia; Promyelocytic leukemia inducer of; Promyelocytic leukemia protein; Protein PML; RING finger protein 71; RNF 71; TRIM 19; Tripartite motif protein TRIM19; Tripartite motif-containing protein 19.

Specificity:

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Rabbit Polyclonal IgG,磷酸化早幼粒细胞白血病蛋白抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human PML Protein around the phosphorylation site of Ser518.

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磷酸化早幼粒细胞白血病蛋白抗体Predicted Molecular Weight: 110kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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