乳腺癌和卵巢癌易感基因RAD51C抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 乳腺癌和卵巢癌易感基因RAD51C抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. 乳腺癌和卵巢癌易感基因RAD51C抗体Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in乳腺癌和卵巢癌易感基因RAD51C抗体 regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.

乳腺癌和卵巢癌易感基因RAD51C抗体Also known as:

tudor domain containing 1; Tdrd1; MTR-1; MTR 1; FLJ21082; CT41.1; TDRD1_HUMAN. Cancer/testis antigen 41.1; TDRD 1; tdrd1; Tudor domain containing protein 1; Tudor domain-containing protein 1.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from human TDRD1.

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Predicted Molecular Weight: 132kDa.

乳腺癌和卵巢癌易感基因RAD51C抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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