磷酸化Ras特异性鸟嘌呤核苷酸释放因子1

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化Ras特异性鸟嘌呤核苷酸释放因子1  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be磷酸化Ras特异性鸟嘌呤核苷酸释放因子1 activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

磷酸化Ras特异性鸟嘌呤核苷酸释放因子1Also known as:

RASGRF1(phospho S929); RASGRF1(phospho Ser929); p-RASGRF1(S929); p-RASGRF1(Ser929); CDC25; CDC25L; GNRP; GRF1; GRF55; Guanine nucleotide exchange factor; Guanine nucleotide releasing factor 55 kD; Guanine nucleotide releasing protein; HGRF55; PP13187; Ras protein specific guanine nucleotide releasing factor 1; Ras specific guanine nucleotide releasing factor;磷酸化Ras特异性鸟嘌呤核苷酸释放因子1 Ras specific guanine nucleotide releasing factor CDC25 homolog; Ras specific nucleotide exchange factor CDC25.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, .

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Immunogen: KLH conjugated Synthesised phosphopeptide derived from human RasGRF1 around the phosphorylation site of Ser929.

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Predicted Molecular Weight: 145kDa.

磷酸化Ras特异性鸟嘌呤核苷酸释放因子1Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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